Effects of Psilocybe argentipes on Marble-Burying Behavior in Mice

@article{Matsushima2009EffectsOP,
  title={Effects of Psilocybe argentipes on Marble-Burying Behavior in Mice},
  author={Yoshihiro Matsushima and Osamu Shirota and Ruri Kikura-Hanajiri and Yukihiro Goda and Fumio Eguchi},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2009},
  volume={73},
  pages={1866 - 1868}
}
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy. 
View on Taylor & Francis
tandfonline.com
22 Citations
Highly Influential Citations
1
Background Citations
5
Results Citations
1

22 Citations

Citation Type

Citation Type

Apotential role for psilocybin in the treatment of obsessive-compulsive disorder
TLDR
Although the current evidence is limited, that multiple signals point in directions consistent with treatment potential, alongside the psychological and physiological safety of clinically administered psilocybin, support the expansion of research, both in animal models and in further randomized controlled trials, to properly investigate this potential.
A potential role for psilocybin in the treatment of obsessive-compulsive disorder
  • E. Jacobs
  • Psychology, Biology
    Journal of Psychedelic Studies
  • 2020
TLDR
Although the current evidence is limited, that multiple signals point in directions consistent with treatment potential, alongside the psychological and physiological safety of clinically administered psilocybin, support the expansion of research, both in animal models and in further randomized controlled trials, to properly investigate this potential.
Long-term Amelioration of OCD Symptoms in a Patient with Chronic Consumption of Psilocybin-containing Mushrooms
TLDR
The case of a male adult with OCD who showed a clinically meaningful reduction of his OCD symptomatology after the consumption of psilocybin-containing mushrooms is presented.
Chronic Corticosterone Pretreatment Reverses Psilocybin’s Effects on Mouse Anxious and Hedonic Behaviors
TLDR
The identified interaction between stress hormone burden and psilocybin behavioral effects in mice suggests the possibility of further developing rodent behavioral models that can assess additional context-dependent effects of psychedelic administration that are deemed clinically-relevant, but are otherwise difficult to control for, in human studies.
Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol: Analytical Methods and Biologic Activities
TLDR
The present article offers an opportunity to find out what are the main symptoms of intoxication with mushrooms containing psilocybin/psilocin, muscimol, and ibotenic acid.
Delayed Anxiolytic-Like Effects of Psilocybin in Male Mice Are Supported by Acute Glucocorticoid Release
TLDR
Rodent studies are suggested as a tractable means to address neuroendocrine mechanisms supporting context-dependent psychedelic effects in mammalian species to identify acute glucocorticoid release as a relevant biological modifier for the post-acute and long-term behavioral effects of psilocybin in mice.
The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward
TLDR
The present review concludes by underlining that the collective translational value of the MBT will be strengthened by contextually valid experimental designs and objective reporting of data.
The Therapeutic Potential of Psilocybin
TLDR
The potential of psilocybin in the treatment of neuropsychiatry-related conditions is explored, examining recent advances as well as current research.
Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years
TLDR
A systematic review of clinical trials published from 1990 until 2015 concluded that ayahuasca, psilocybin and LSD may be useful pharmacological tools for the treatment of drug dependence, and anxiety and mood disorders, especially in treatment-resistant patients.
...
...

References

SHOWING 1-10 OF 26 REFERENCES
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.
TLDR
It is suggested that perospirone may exhibit anti-OCD activity in clinical use and that 5-HT(1A)-receptor agonistic activity may be involved in the inhibition of marble-burying behavior by perospIRone.
Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice
TLDR
Among novel antipsychotics with dual D2/5-HT1A properties, only bifeprunox was able to potently reduce the number of buried marbles, as well as a series of receptor subtype-selective ligands.
Concise large-scale synthesis of psilocin and psilocybin, principal hallucinogenic constituents of "magic mushroom".
The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal hallucinogenic constituents of "magic mushroom", were achieved without chromatographic purification. The key step…
SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder.
TLDR
In a controlled clinical environment, psilocybin was safely used in subjects with OCD and was associated with acute reductions in core OCD symptoms in several subjects.
Aeruginascin, a trimethylammonium analogue of psilocybin from the hallucinogenic mushroom Inocybe aeruginascens.
TLDR
The structure of a further indole derivative named aeruginascin is elucidated as the quaternary ammonium compound N,N, N-trimethyl-4-phosphoryloxytryptamine, closely related to the frog skin toxin bufotenidine (5-HTQ), a potent 5-HT3 receptor agonist, and has been found exclusively in Inocybe aerug inascens so far.
Evaluation of marble-burying behavior as a model of anxiety
Psychoactive tryptamines from basidiomycetes
TLDR
The biosynthesis and production of some tryptamines by the mycelial culture ofPsilocybe bohemicaŠebek is described, and a survey of methods for their analysis and isolation is conducted.
5-HT1A-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice.
TLDR
From these results, the 5-HT1A-receptor subtype may be involved in the suppressive effect of fluvoxamine on the marble-burying, but the5-HT2-re receptor subtype is not involved in this effect.
Hallucinogens, serotonin and obsessive-compulsive disorder.
TLDR
Clinical and preclinical data suggest that activation of 5-HT2 receptors by hallucinogens may lead to acute reduction of, as well as possible longer-lasting beneficial effects on, the symptoms of OCD.
...
...