Effects of Porphyromonas gingivalis on cell cycle progression and apoptosis of primary human chondrocytes.

@article{Pischon2009EffectsOP,
  title={Effects of Porphyromonas gingivalis on cell cycle progression and apoptosis of primary human chondrocytes.},
  author={Nicole Pischon and Eric R{\"o}hner and Andreas Hocke and Prudence N'guessan and Holger Christian M{\"u}ller and Georg Matziolis and Veronika Kanitz and Peter Purucker and B Kleber and Jean P Bernimoulin and Gerd R. Burmester and Frank Buttgereit and Jacqueline Detert},
  journal={Annals of the rheumatic diseases},
  year={2009},
  volume={68 12},
  pages={
          1902-7
        }
}
BACKGROUND It has been suggested that bacterial infections have a role in the pathogenesis of rheumatoid arthritis (RA). P gingivalis, a Gram-negative, anaerobic rod, is one of the major pathogens associated with periodontal disease. OBJECTIVE To examine P gingivalis infection and its effects on cell cycle progression and apoptosis of human articular chondrocytes. METHODS Primary human chondrocytes cultured in monolayers were challenged with P gingivalis. Infection and invasion of P… CONTINUE READING
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