Effects of Porphyromonas gingivalis culture products on human polymorphonuclear leukocyte function.

@article{Wilton1990EffectsOP,
  title={Effects of Porphyromonas gingivalis culture products on human polymorphonuclear leukocyte function.},
  author={Jeanne M Wilton and T J Hurst and R J Carman and Marion G Macey},
  journal={FEMS microbiology immunology},
  year={1990},
  volume={2 5-6},
  pages={285-93}
}
Porphyromonas gingivalis culture supernate was found to induce homotypic agglutination of human polymorphonuclear leukocytes (PMN). Pretreatment of PMN with P. gingivalis supernate inhibited both the rate and the degree of agglutination induced by the secretagogues PMA and FMLP. Lipopolysaccharide from P. gingivalis upregulated the CR3 (Mac-1, CD11b) receptors on PMN. Treatment of glass-adherent PMN with P. gingivalis supernate did not alter their phagocytic capacity for P. gingivalis cells but… CONTINUE READING