Effects of Phenylalanine on the Liquid-Expanded and Liquid-Condensed States of Phosphatidylcholine Monolayers

@article{Cutr2019EffectsOP,
  title={Effects of Phenylalanine on the Liquid-Expanded and Liquid-Condensed States of Phosphatidylcholine Monolayers},
  author={Andrea C. Cutr{\'o} and E A Disalvo and Maria A. Frias},
  journal={Lipid insights},
  year={2019},
  volume={12}
}
Background Phenylalanine (Phe) is involved in physiological and pathological processes in cell membranes in which expanded and condensed states coexist. In this direction, it was reported that surface hydration is important for the binding affinity of the amino acid which significantly perturbs 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer structure and morphology. A deeper insight showed that Phe inserts in DPPC monolayer defects as a monomer at pH 5 and forms aggregates that… Expand
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TLDR
Generalized polarization of 14:0 Diether PC in correlation with FTIR analysis indicates a higher level of polarizability of water molecules in the membrane phase around the phosphate groups both below and above Tm. Expand

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