Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen

  title={Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen},
  author={Aurelia H. M. de Vries Schultink and Wilbert Zwart and Sabine Linn and Jos H. Beijnen and Alwin D. R. Huitema},
  booktitle={Clinical pharmacokinetics},
The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. Tamoxifen is bioactivated by cytochrome P450 (CYP) enzymes such as CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5, resulting in the formation of active metabolites, including 4-hydroxy-tamoxifen and… CONTINUE READING


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