Effects of Pharmaceuticals on Aquatic Invertebrates. Part II: The Antidepressant Drug Fluoxetine

@article{Nentwig2007EffectsOP,
  title={Effects of Pharmaceuticals on Aquatic Invertebrates. Part II: The Antidepressant Drug Fluoxetine},
  author={Gerrit Nentwig},
  journal={Archives of Environmental Contamination and Toxicology},
  year={2007},
  volume={52},
  pages={163-170}
}
  • G. Nentwig
  • Published 2007
  • Biology, Medicine
  • Archives of Environmental Contamination and Toxicology
Fluoxetine, a selective serotonin reuptake inhibitor antidepressant and high-prescription-volume drug, is excreted unchanged or as a glucuronide from the human organism. Little is known about its fate in sewage treatment plants. Effects of fluoxetine on life-cycle parameters of the midge Chironomus riparius, especially development (mean emergence time), emergence, sex ratio, and fecundity, were assessed, as well as effects on reproduction of the oligochaete Lumbriculus variegatus and of the… Expand
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Differences in sublethal responses to fluoxetine enantiomers suggest that enantiospecific toxicity and mode-of-action related responses that are ecologically relevant (e.g., feeding rate) should be considered in future ecological hazard and risk assessments for chiral contaminants. Expand
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