Effects of Pasteurella multocida toxin on porcine bone marrow cell differentiation into osteoclasts and osteoblasts.

@article{Gwaltney1997EffectsOP,
  title={Effects of Pasteurella multocida toxin on porcine bone marrow cell differentiation into osteoclasts and osteoblasts.},
  author={Sharon Gwaltney and Rachelle J Sells Galvin and Karen B. Register and Richard B. Rimler and Mark R Ackermann},
  journal={Veterinary pathology},
  year={1997},
  volume={34 5},
  pages={421-30}
}
The effect of Pasteurella multocida toxin (PMT) on porcine osteoclast and osteoblast differentiation was studied using in vitro cell culture systems. When grown in the presence of Vitamin D3, isolated porcine bone marrow cells formed multinucleated cells with features characteristic of osteoclasts. Exposure of bone marrow cells to Vitamin D3 and PMT during growth resulted in formation of increased numbers and earlier appearance of osteoclasts compared to controls. Ultrafiltered medium form PMT… CONTINUE READING
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