Effects of Pacing Site and Stimulation History on Alternans Dynamics and the Development of Complex Spatiotemporal Patterns in Cardiac Tissue

@inproceedings{Gizzi2013EffectsOP,
  title={Effects of Pacing Site and Stimulation History on Alternans Dynamics and the Development of Complex Spatiotemporal Patterns in Cardiac Tissue},
  author={A Gizzi and Elizabeth M. Cherry and Robert F. Gilmour and Stefan Luther and Simonetta Filippi and Flavio H. Fenton},
  booktitle={Front. Physiol.},
  year={2013}
}
Alternans of action potential duration has been associated with T wave alternans and the development of arrhythmias because it produces large gradients of repolarization. However, little is known about alternans dynamics in large mammalian hearts. Using optical mapping to record electrical activations simultaneously from the epicardium and endocardium of 9 canine right ventricles, we demonstrate novel arrhythmogenic complex spatiotemporal dynamics. (i) Alternans predominantly develops first on… CONTINUE READING