Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men.

@article{Schmidt2014EffectsOP,
  title={Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men.},
  author={Julie Berg Schmidt and Nikolaj Ture Gregersen and Sue D. Pedersen and Johanne Louise Arentoft and Christian Ritz and Thue W. Schwartz and Jens Juul Holst and Arne Astrup and Anders M. Sj{\"o}din},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={306 11},
  pages={
          E1248-56
        }
}
Our aim was to examine the effects of GLP-1 and PYY3-36, separately and in combination, on energy intake, energy expenditure, appetite sensations, glucose and fat metabolism, ghrelin, and vital signs in healthy overweight men. Twenty-five healthy male subjects participated in this randomized, double-blinded, placebo-controlled, four-arm crossover study (BMI 29 ± 3 kg/m(2), age 33 ± 9 yr). On separate days they received a 150-min intravenous infusion of 1) 0.8 pmol·kg(-1)·min(-1) PYY3-36, 2) 1.0… 
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References

SHOWING 1-10 OF 44 REFERENCES

Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects.

Peptide YY (PYY)(3-36) has been shown to produce dramatic reductions in energy intake (EI), but no human data exist regarding energy expenditure (EE), glucose and fat metabolism. Nothing is known…

Effect of peptide YY3-36 on food intake in humans.

This study shows that intravenous infusions of PYY3-36 decrease spontaneous food intake; the inhibition is, however, only significant at pharmacologic plasma concentrations.

Attenuated peptide YY release in obese subjects is associated with reduced satiety.

Obese subjects have a PYY deficiency that would reduce satiety and could thus reinforce their obesity, and fasting and postprandial endogenous plasma PYY levels were attenuated in obese humans and rodents.

The Gut Hormones PYY3-36 and GLP-17-36 amide Reduce Food Intake and Modulate Brain Activity in Appetite Centers in Humans

Inhibition of food intake in obese subjects by peptide YY3-36.

It is found that obese subjects were not resistant to the anorectic effects of PYY, and endogenous PYY levels were low in obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity.

Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively.

PYY(3-36) and GLP-1(7-36), cosecreted after a meal, may inhibit food intake additively and is studied in rodents and man.

Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men

Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects.

A marked effect of orally administered GLP-1 and PYY3-36 on appetite is shown by showing enhanced fullness at meal onset and reduced energy intake, with marked effects on glucose homeostasis.

Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice.

It is suggested that administration of low doses of Ex4 together with PYY(3-36NH2) may increase the suppression of FI without inducing significant side effects, and this work confirms that cosecreted peptides regulate food intake in rodents and humans via independent mechanisms.

A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans.

The aim was to examine the effect of glucagon-like peptide-1 on subsequent energy intake using a data set composed of subject data from previous studies and from two as yet unpublished studies, and investigate whether the effect on energy intake is dose dependent and differs between lean and overweight subjects.