Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.

@article{Nahi2004EffectsOP,
  title={Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.},
  author={Hareth Nahi and S{\"o}ren Lehmann and Lars Mollgard and Sofia Bengtz{\'e}n and Galina Selivanova and Klas G Wiman and Christer Paul and Mats Merup},
  journal={British journal of haematology},
  year={2004},
  volume={127 3},
  pages={285-91}
}
The tumour suppressor gene p53 is the most commonly mutated gene in solid tumours. Although less common in haematological malignancies, 10-15% of B-cell chronic lymphocytic leukaemia (B-CLL) cases carry a p53 mutation. Recently, the compound P53-dependent reactivation and induction of massive apoptosis (PRIMA-1) has been shown to induce cytotoxic effects and apoptosis in human tumour cells by restoration of the transcriptional activity of mutated p53. This is believed to be mediated by a change… CONTINUE READING

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