Effects of PGI2 analogues on Th1- and Th2-related chemokines in monocytes via epigenetic regulation

  title={Effects of PGI2 analogues on Th1- and Th2-related chemokines in monocytes via epigenetic regulation},
  author={Chang-Hung Kuo and Y. Ko and S. Yang and Yu-Te Chu and Weili Wang and S. Huang and Huan-Nan Chen and Wan-Ju Wei and Y. Jong and C. Hung},
  journal={Journal of Molecular Medicine},
  • Chang-Hung Kuo, Y. Ko, +7 authors C. Hung
  • Published 2010
  • Biology, Medicine
  • Journal of Molecular Medicine
  • Chemokines play important roles in asthma. Prostaglandin I2 (PGI2) analogue is recently suggested as a candidate for treating asthma. However, the effects of PGI2 analogues on the expression of Th1- and Th2-related chemokines are unknown. To this end, we investigated the in vitro effects of PGI2 analogues on the expression of Th1-related chemokine interferon-γ-inducible protein-10 (IP-10/CXCL10) and Th2-related chemokine macrophage-derived chemokine (MDC/CCL22) in human monocytes. The human… CONTINUE READING
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