Effects of Oxytocin and Prosocial Behavior on Brain Responses to Direct and Vicariously Experienced Pain

@article{Singer2008EffectsOO,
  title={Effects of Oxytocin and Prosocial Behavior on Brain Responses to Direct and Vicariously Experienced Pain},
  author={T. Singer and R. Snozzi and G. Bird and P. Petrovi{\'c} and G. Silani and M. Heinrichs and R. Dolan},
  journal={Emotion (Washington, D.C.)},
  year={2008},
  volume={8},
  pages={781 - 791}
}
  • T. Singer, R. Snozzi, +4 authors R. Dolan
  • Published 2008
  • Psychology, Medicine
  • Emotion (Washington, D.C.)
  • In this study, we tested the validity of 2 popular assumptions about empathy: (a) empathy can be enhanced by oxytocin, a neuropeptide known to be crucial in affiliative behavior, and (b) individual differences in prosocial behavior are positively associated with empathic brain responses. To do so, we measured brain activity in a double-blind placebo-controlled study of 20 male participants either receiving painful stimulation to their own hand (self condition) or observing their female partner… CONTINUE READING
    219 Citations

    Figures, Tables, and Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
    This experiment will explore the joint effects of social information, social support, associative learning, and oxytocin on the development of placebo analgesia. The investigators… Expand
    ConditionsPain
    InterventionDrug
    Interventional Clinical Trial
    Oxytocin is a neuropeptide that is well known for its role in social and affiliative behavior in humans. Oxytocin receptors are significantly lowered in autistic individuals and… Expand
    ConditionsBrain Dynamics in Healthy Adults
    InterventionDrug
    Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans
    • 586
    • Highly Influenced
    • PDF
    Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity
    • 35
    • PDF
    Oxytocin Effects on Pain Perception and Pain Anticipation.
    • 7
    Oxytocin facilitates protective responses to aversive social stimuli in males
    • 198
    • PDF
    Oxytocin modulates fMRI responses to facial expression in macaques
    • 45
    • PDF

    References

    SHOWING 1-10 OF 74 REFERENCES
    Empathic neural responses are modulated by the perceived fairness of others
    • 1,379
    • PDF
    The Neural Substrate of Human Empathy: Effects of Perspective-taking and Cognitive Appraisal
    • 1,096
    • Highly Influential
    • PDF
    Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
    • 1,352
    • Highly Influential
    • PDF
    Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
    • 1,588
    • PDF
    Empathy and judging other's pain: an fMRI study of alexithymia.
    • 342
    • PDF
    I feel how you feel but not always: the empathic brain and its modulation
    • 450
    • PDF
    Selective amnesic effects of oxytocin on human memory
    • 150
    Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
    • 401
    • PDF
    Attention and reality constraints on the neural processes of empathy for pain
    • 295
    • PDF