Effects of Overexpression of the Na 1-Ca 2 1 Exchanger on [ Ca 2 1 ] i Transients in Murine Ventricular Myocytes

@inproceedings{Yao1998EffectsOO,
  title={Effects of Overexpression of the Na 1-Ca 2 1 Exchanger on [ Ca 2 1 ] i Transients in Murine Ventricular Myocytes},
  author={Atsushi Yao and Zhi xing Su and Akihiko Nonaka and Iram Zubair and Liyan Lu and Kenneth D. Philipson and John H. B. Bridge and William H. Barry},
  year={1998}
}
We measured [Ca ]i and [Na ]i in isolated transgenic (TG) mouse myocytes overexpressing the Na -Ca exchanger and in wild-type (WT) myocytes. In TG myocytes, the peak systolic level and amplitude of electrically stimulated (ES) [Ca ]i transients (0.25 Hz) were not significantly different from those in WT myocytes, but the time to peak [Ca ]i was significantly prolonged. The decline of ES [Ca ]i transients was significantly accelerated in TG myocytes. The decline of a long-duration (4-s) caffeine… CONTINUE READING
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