Effects of Ougan juice on P450 activities using a cocktail method.

@article{Lin2012EffectsOO,
  title={Effects of Ougan juice on P450 activities using a cocktail method.},
  author={Guan-yang Lin and Jian-She Ma and Ren-ai Xu and Lu-feng Hu and Zhe Wang and Xianqin Wang},
  journal={Die Pharmazie},
  year={2012},
  volume={67 3},
  pages={242-6}
}
Ougan (Citrus suavissima Hort. ex Tanaka) is an important domesticated fruit which is used medicinally in China. To date, a number of methods for its identification and chemical analysis have been studied. However, the effects of Ougan juice on CYP isozymes have not been reported. Therefore, the objective of our study was to evaluate the potential effects of Ougan juice on the CYP isozymes CYP1A2, CYP2C9, CYP2C19 and CYP2D6 in rats using a cocktail approach involving the probe drugs phenacetin… CONTINUE READING
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