Effects of Orlistat, a Lipase Inhibitor, on the Pharmacokinetics of Three Highly Lipophilic Drugs (Amiodarone, Fluoxetine, and Simvastatin) in Healthy Volunteers

@article{Zhi2003EffectsOO,
  title={Effects of Orlistat, a Lipase Inhibitor, on the Pharmacokinetics of Three Highly Lipophilic Drugs (Amiodarone, Fluoxetine, and Simvastatin) in Healthy Volunteers},
  author={J. Zhi and R. Moore and Linda Kanitra and Thomas E Mulligan},
  journal={The Journal of Clinical Pharmacology},
  year={2003},
  volume={43}
}
  • J. Zhi, R. Moore, +1 author Thomas E Mulligan
  • Published 2003
  • Medicine
  • The Journal of Clinical Pharmacology
  • To investigate the effect of orlistat on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin), the authors performed double‐blind, placebo‐controlled, randomized two‐period crossover (for fluoxetine and simvastatin) or parallel (for amiodarone) studies in healthy volunteers ages 18 to 65 years of a body mass index between 18 and 30 kg/m2. During treatment with orlistat or matching placebo for 5 to 13 ⅓ days, a single oral dose of highly lipophilic drug… CONTINUE READING
    54 Citations
    Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats
    • 11
    • PDF
    Investigating herb-drug interactions: the effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats.
    • 14
    • PDF
    Herb-drug interaction of Fucus vesiculosus extract and amiodarone in rats: a potential risk for reduced bioavailability of amiodarone in clinical practice.
    • 15
    Effect of permeation enhancers on transdermal delivery of fluoxetine: in vitro and in vivo evaluation.
    • 29
    • Highly Influenced
    The use of orlistat in the treatment of obesity, dyslipidaemia and Type 2 diabetes
    • 20
    Pharmacotherapy for obesity
    • 4
    • PDF

    References

    SHOWING 1-10 OF 19 REFERENCES
    Effect of the lipase inhibitor orlistat on the pharmacokinetics of four different antihypertensive drugs in healthy volunteers
    • 29
    The Influence of Orlistat on the Pharmacokinetics and Pharmacodynamics of Glyburide in Healthy Volunteers
    • 31
    The Effect of Orlistat on the Pharmacokinetics of Phenytoin in Healthy Volunteers
    • 30
    The Effect of Orlistat on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers
    • 44
    The interaction of the lipase inhibitor orlistat with ethanol in healthy volunteers
    • 16
    The Influence of Reduced Dietary Fat Absorption Induced by Orlistat on the Pharmacokinetics of Digoxin in Healthy Volunteers
    • 33