Effects of Oral Cimetidine or Ranitidine on the Pharmacokinetics of Intravenous Enoxacin

@article{Misiak1993EffectsOO,
  title={Effects of Oral Cimetidine or Ranitidine on the Pharmacokinetics of Intravenous Enoxacin},
  author={P M Misiak and Michael A. Eldon and Roger D. Toothaker and Allen J. Sedman},
  journal={The Journal of Clinical Pharmacology},
  year={1993},
  volume={33}
}
Enoxacin is a quinolone antibacterial agent currently being developed for oral and intravenous treatment of bacterial infections. Ten healthy subjects received a single 400‐mg intravenous dose of enoxacin alone, with 300 mg (four times daily) oral Cimetidine and with 150 mg (twice daily) oral ranitidine. Serial blood and urine samples were collected over a 48‐hour period. Plasma and urine enoxacin concentrations were determined using a validated high‐performance liquid chromatographic method… 
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