Effects of Monosodium glutamate on the Serum Estrogen and Progesterone Levels in Female rats and Prevention of this Effects with Ditiazem
- S. Z Muhammad, Q Khadija, Rhuhila, H amd Mohazzam
- Journal of Ayum Medical College Abbuttabad
Background: The objective of this study was to evaluate the effect of 4 selected food seasonings (labeled IS, KC, SMC and BS) commonly consumed in Nigeria on some sex hormonesTestosterone, Estrogen and Progesterone of wistar albino rats. Method: A total of 117 male and female rats with average weight of 120g were used. Animals were grouped into 5 groups, with 9 rats in each group. Group 1 represents the control, while group 2-5 represents the treatment group. Oral administration of 1mg/g, 2mg/g and 4mg/g body weight of each seasoning were administered to rats in the treatment group. Those in the control group received growers mash and water. From each group, 3 rats were sacrificed weekly for 3 weeks to determine the serum concentrations of these sex hormones. Result: This showed a dose dependent increase in the weight of rats. There was a significant (P<0.05) decrease in the concentration of the male sex hormonetestosterone in treated rats. Also, a significant (P<0.05) increase in the concentration of the female reproductive hormones-estrogen and progesterone was observed in treated rats when compared with the control. Conclusion: These observations, suggests that components of these seasonings may have the ability of altering the normal concentrations of these sex hormones.