Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch

@article{Bouskela1997EffectsOO,
  title={Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch},
  author={Eliete Bouskela and K. A. Donyo},
  journal={Angiology},
  year={1997},
  volume={48},
  pages={391 - 399}
}
The effects of a clinically used purified micronized flavonoid fraction (S 5682) containing 90% diosmin and 10% hesperidin on increased microvascular permeability induced by histamine, bradykinin, and leukotriene B4 (LTB4) were investigated by intravital microscopy in the hamster cheek pouch preparation. The authors also investigated the effects of S 5682 on macromolecular permeability increase and leukocyte adhesion during ischemia-reperfusion by using the same preparation. S 5682, suspended… 

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Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischaemia/reperfusion in the hamster cheek pouch

The results indicate that S5682 improves the microvascular reactivity and FCD after ischaemia/reperfusion, which may explain its beneficial therapeutic effect in chronic venous insufficiency where oxidative stress is involved in the pathological mechanism.

Microvascular Reactivity After Ischemia/Reperfusion in the Hamster Cheek Pouch: Beneficial Effects of Different Oral Doses of S-5682 (Daflon 500 mg)

It is demonstrated that oral administration of different doses of S-5682 for ten days improved the microvascular reactivity and FCD after ischemia/reperfusion in a dose-dependent fashion in the hamster cheek pouch microvasculature.

Leukocyte Adhesion after Oxidant Challenge in the Hamster Cheek Pouch Microcirculation

The inhibition of oxidant-induced leukocyte adhesion was similar to that seen for ischemia-reperfusion and the higher dose of S-5682 was as effective as α-tocopherol in inhibiting it.

Purified Micronized Flavonoid Fraction Ameliorates the Injury of Spleen and Ileum Secondary to Hepatic Ischemia–Reperfusion in Rats

The results of this study indicated that MPFF pretreatment significantly limited the injury to the small intestine and spleen induced by hepatic ischemia–reperfusion in rats.

The Effect of Purified Micronized Flavonoid Fraction on the Healing of Anastomoses in the Colon in Rats

Although the micronized purified flavonoid fraction has some inhibitory properties on the healing of the anastomosis, its net effect was to obtain a better anASTomotic healing ofThe colon in rats.

Efficacy of micronized flavonoid fraction in healing of clean and infected wounds

It was showed that oral or topical administration of micronized flavonoid fraction in the infected wounds is beneficial, while it has no significant effect in clean wounds.

Micronised Purified Flavonoid Fraction

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Clinical acceptability study of micronized purified flavonoid fraction 1000 mg tablets versus 500 mg tablets in patients suffering acute hemorrhoidal disease

After 7 days of treatment with MPFF at the same daily dose, both regimens reduced anal pain and bleeding and MPFF 1000 mg had a comparable safety profile to MPFF 500’mg, with the advantage of fewer tablets.
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