Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch

@article{Bouskela1997EffectsOO,
  title={Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch},
  author={Eliete Bouskela and K. A. Donyo},
  journal={Angiology},
  year={1997},
  volume={48},
  pages={391 - 399}
}
The effects of a clinically used purified micronized flavonoid fraction (S 5682) containing 90% diosmin and 10% hesperidin on increased microvascular permeability induced by histamine, bradykinin, and leukotriene B4 (LTB4) were investigated by intravital microscopy in the hamster cheek pouch preparation. The authors also investigated the effects of S 5682 on macromolecular permeability increase and leukocyte adhesion during ischemia-reperfusion by using the same preparation. S 5682, suspended… Expand
Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischaemia/reperfusion in the hamster cheek pouch
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The results indicate that S5682 improves the microvascular reactivity and FCD after ischaemia/reperfusion, which may explain its beneficial therapeutic effect in chronic venous insufficiency where oxidative stress is involved in the pathological mechanism. Expand
Microvascular Reactivity After Ischemia/Reperfusion in the Hamster Cheek Pouch: Beneficial Effects of Different Oral Doses of S-5682 (Daflon 500 mg)
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Data indicate that Daflon 500 mg preserves the endothelial barrier function of striated skin muscle arterioles and venules after I/R, which appears to be independent of an action on postischemic intravascular leukocyte rolling and sticking. Expand
ects of oral administration of di erent doses of puri ® ed micronized ̄ avonoid fraction on microvascular reactivity after ischaemia / reperfusion in the hamster cheek pouch
1 The e€ects of a puri®ed micronized ̄avonoid fraction (S5682) on mean internal diameter and blood ̄ow of arterioles and venules, as well as the functional capillary density (FCD) were evaluated inExpand
Leukocyte Adhesion after Oxidant Challenge in the Hamster Cheek Pouch Microcirculation
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The inhibition of oxidant-induced leukocyte adhesion was similar to that seen for ischemia-reperfusion and the higher dose of S-5682 was as effective as α-tocopherol in inhibiting it. Expand
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It is demonstrated that micronized purified flavonoid fraction ameliorates I/R-induced liver damage, probably through antioxidant and anti-inflammatory properties. Expand
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Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids.
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TLDR
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