Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch

@article{Bouskela1997EffectsOO,
  title={Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch},
  author={Eliete Bouskela and K. A. Donyo},
  journal={Angiology},
  year={1997},
  volume={48},
  pages={391 - 399}
}
The effects of a clinically used purified micronized flavonoid fraction (S 5682) containing 90% diosmin and 10% hesperidin on increased microvascular permeability induced by histamine, bradykinin, and leukotriene B4 (LTB4) were investigated by intravital microscopy in the hamster cheek pouch preparation. The authors also investigated the effects of S 5682 on macromolecular permeability increase and leukocyte adhesion during ischemia-reperfusion by using the same preparation. S 5682, suspended… 

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Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischaemia/reperfusion in the hamster cheek pouch

The results indicate that S5682 improves the microvascular reactivity and FCD after ischaemia/reperfusion, which may explain its beneficial therapeutic effect in chronic venous insufficiency where oxidative stress is involved in the pathological mechanism.

Microvascular Reactivity After Ischemia/Reperfusion in the Hamster Cheek Pouch: Beneficial Effects of Different Oral Doses of S-5682 (Daflon 500 mg)

It is demonstrated that oral administration of different doses of S-5682 for ten days improved the microvascular reactivity and FCD after ischemia/reperfusion in a dose-dependent fashion in the hamster cheek pouch microvasculature.

Beneficial effects of the micronized purified flavonoid fraction (MPFF*, Daflon® 500 mg) on microvascular damage elicited by sclerotherapy

MPFF treatment limited the postsclerotherapy inflammation in surrounding microvascular network, suggesting that MPFF may prevent undesirable secondary effects of the procedure in this animal model.

ects of oral administration of di erent doses of puri ® ed micronized ̄ avonoid fraction on microvascular reactivity after ischaemia / reperfusion in the hamster cheek pouch

The results indicate that S5682 improves the microvascular reactivity and FCD after ischaemia/reperfusion, and suggest that it could function as an antioxidant in chronic venous insuciency where oxidative stress is involved in the pathological mechanism.

Leukocyte Adhesion after Oxidant Challenge in the Hamster Cheek Pouch Microcirculation

The inhibition of oxidant-induced leukocyte adhesion was similar to that seen for ischemia-reperfusion and the higher dose of S-5682 was as effective as α-tocopherol in inhibiting it.

Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids.

In conclusion, MPFF is a well established and well tolerated treatment option in patients with CVI, venous ulcers, or acute or chronic internal haemorrhoids, and is indicated as a first-line treatment of oedema and the symptoms of CVI in patients in any stage of the disease.
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