Effects of Olanzapine on Regional C-Fos Expression in Rat Forebrain

@article{Robertson1996EffectsOO,
  title={Effects of Olanzapine on Regional C-Fos Expression in Rat Forebrain},
  author={George R. Robertson and H. Christian Fibiger},
  journal={Neuropsychopharmacology},
  year={1996},
  volume={14},
  pages={105-110}
}
Compared to typical antipsychotic drugs, clozapine produces a unique pattern of Fos-like immunoreactive neurons in the rat forebrain. It has been proposed, therefore, that this approach may be useful in identifying other agents with clozapine's therapeutic profile. In the present study, we examined the ability of olanzapine to increase the number of Fos-like immunoreactive neurons in the striatum, nucleus accumbens, lateral septal nucleus, and prefrontal cortex. Olanzapine (5, 10 mg/kg… CONTINUE READING
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