Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers

  title={Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers},
  author={Julia Sacher and Nilufar Mossaheb and Christoph Spindelegger and Nikolas Klein and Thomas Geiss-Granadia and Robert Sauermann and Edith Lackner and Christian Joukhadar and Markus A. M{\"u}ller and Siegfried Kasper},
Atypical antipsychotics have been linked to a higher risk for glucose intolerance, and consequentially the development of type 2 diabetes mellitus (DM2). We have therefore set out to investigate the acute effects of oral administration of olanzapine and ziprasidone on whole body insulin sensitivity in healthy subjects. Using the standardized hyperinsulinemic euglycemic clamp technique we compared whole body insulin sensitivity of 29 healthy male volunteers after oral intake of either olanzapine… CONTINUE READING
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Lilly lecture 1989

  • RN Bergman
  • Toward physiological understanding of glucose…
  • 1989
Highly Influential
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