Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers

@article{Sacher2008EffectsOO,
  title={Effects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers},
  author={J. Sacher and N. Mossaheb and C. Spindelegger and N. Klein and T. Geiss-Granadia and R. Sauermann and E. Lackner and C. Joukhadar and M. Müller and S. Kasper},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={1633-1641}
}
  • J. Sacher, N. Mossaheb, +7 authors S. Kasper
  • Published 2008
  • Medicine
  • Neuropsychopharmacology
  • Atypical antipsychotics have been linked to a higher risk for glucose intolerance, and consequentially the development of type 2 diabetes mellitus (DM2). We have therefore set out to investigate the acute effects of oral administration of olanzapine and ziprasidone on whole body insulin sensitivity in healthy subjects. Using the standardized hyperinsulinemic euglycemic clamp technique we compared whole body insulin sensitivity of 29 healthy male volunteers after oral intake of either olanzapine… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The primary aim of this study is to investigate antipsychotic drug effects on healthy brain metabolism.  
    ConditionsHealthy
    InterventionDrug
    Metformin attenuates olanzapine-induced hepatic, but not peripheral insulin resistance.
    • 16
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 75 REFERENCES
    Hyperglycemic clamp assessment of insulin secretory responses in normal subjects treated with olanzapine, risperidone, or placebo.
    • 131
    • Highly Influential
    • PDF
    Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia.
    • 498
    • Highly Influential
    • PDF
    Clinical outcome and olanzapine plasma levels in acute schizophrenia.
    • 64
    Olanzapine plasma concentrations and clinical response in acutely ill schizophrenic patients.
    • 110
    Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia.
    • 808
    • PDF
    Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    • 4,708
    • PDF