Effects of ONO-1078, a peptide leukotriene antagonist, on endotoxin-induced acute lung injury.

@article{Ishizaka1994EffectsOO,
  title={Effects of ONO-1078, a peptide leukotriene antagonist, on endotoxin-induced acute lung injury.},
  author={Akitoshi Ishizaka and Naoki Hasegawa and Fumio Sakamaki and Sadatomo Tasaka and Hidetoshi Nakamura and Katsuya Kishikawa and Arisa Yamada and Takayuki Obata and Koichi Sayama and T. Urano},
  journal={American journal of respiratory and critical care medicine},
  year={1994},
  volume={150 5 Pt 1},
  pages={1325-31}
}
The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS group (n = 9) injected intravenously with 2 mg E. coli LPS, an ONO group (n = 8) receiving 30 mg/kg of intraperitoneal ONO, and an LPS+ONO group (n = 6) receiving 30 mg/kg of ONO… CONTINUE READING