Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2.

@article{Tilden1987EffectsOO,
  title={Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2.},
  author={Samuel J. Tilden and David C. Underwood and Kimberly H. Cowen and M. J. Wegmann and Gwendolyn B. Graybar and Albert L. Hyman and Dennis B. McNamara and Philip J. Kadowitz},
  journal={Journal of applied physiology},
  year={1987},
  volume={62 5},
  pages={
          2066-74
        }
}
The influence of OKY 1581, a thromboxane synthase inhibitor, on airway responses to arachidonic acid and endoperoxide, [prostaglandin (PG) H2], were investigated in anesthetized, paralyzed, mechanically ventilated cats. Intravenous injections of arachidonic acid and PGH2 caused dose-related increases in transpulmonary pressure and lung resistance and decreases in dynamic and static compliance. OKY 1581 significantly decreased airway responses to arachidonic acid but not to PGH2. Sodium… Expand
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