Effects of Noncompetitive NMDA Receptor Blockade on Anterior Cingulate Cerebral Blood Flow in Volunteers with Schizophrenia

@article{Holcomb2005EffectsON,
  title={Effects of Noncompetitive NMDA Receptor Blockade on Anterior Cingulate Cerebral Blood Flow in Volunteers with Schizophrenia},
  author={Henry H. Holcomb and A. C. Lahti and Deborah R. Medoff and Tom Cullen and Carol A. Tamminga},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={2275-2282}
}
Schizophrenia may be related to dysfunctional glutamatergic activity, specifically hypofunction of the N-methyl-D-aspartate receptor (NMDAR). In addition, it has been proposed that NMDAR hypofunction may paradoxically cause an increase in glutamate release and hypermetabolism in corticolimbic regions. If a state of partial, chronic NMDAR blockade underlies schizophrenia, then schizophrenic volunteers (SV) may have greater glutamate release and associated elevations in regional cerebral blood… CONTINUE READING
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