Effects of Nickel, Chlorpyrifos and Their Mixture on the Dictyostelium discoideum Proteome

@article{Boatti2012EffectsON,
  title={Effects of Nickel, Chlorpyrifos and Their Mixture on the Dictyostelium discoideum Proteome},
  author={L. Boatti and E. Robotti and E. Marengo and A. Viarengo and F. Marsano},
  journal={International Journal of Molecular Sciences},
  year={2012},
  volume={13},
  pages={15679 - 15705}
}
Mixtures of chemicals can have additive, synergistic or antagonistic interactions. We investigated the effects of the exposure to nickel, the organophosphate insecticide chlorpyrifos at effect concentrations (EC) of 25% and 50% and their binary mixture (Ec25 + EC25) on Dictyostelium discoideum amoebae based on lysosomal membrane stability (LMS). We treated D. discoideum with these compounds under controlled laboratory conditions and evaluated the changes in protein levels using a two… Expand
Synergistic Effects of Heavy Metals and Pesticides in Living Systems

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