Effects of Niacin Restriction on Sirtuin and PARP Responses to Photodamage in Human Skin

@inproceedings{Benavente2012EffectsON,
  title={Effects of Niacin Restriction on Sirtuin and PARP Responses to Photodamage in Human Skin},
  author={Claudia A. Benavente and Stephanie A. Schnell and Elaine L. Jacobson},
  booktitle={PloS one},
  year={2012}
}
Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses. Skin is frequently exposed to the DNA damaging effects of UV irradiation, a known etiology in skin cancer. Thus, understanding the defense mechanisms in response to UV, including the role of SIRTs and PARPs, may be important in developing skin cancer prevention strategies. Here, we report expression of the seven SIRT family members in human… CONTINUE READING

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