Effects of Natural Moisturizing Factor and Lactic Acid Isomers on Skin Function

  title={Effects of Natural Moisturizing Factor and Lactic Acid Isomers on Skin Function},
  author={Clive Roderick Harding and Anthony V Rawlings},
A global perspective on caring for healthy stratum corneum by mitigating the effects of daily cleansing: report from an expert dermatology symposium
A symposium was held in October 2011 on skin cleansing and its role in basic skin care. The meeting was attended by an international group of leading dermatologists.
Essential Fatty Acids and Atopic Dermatitis
Intervention studies suggest that omega-6 fatty acids, especially γ-linolenic acid, may be useful for mild atopic conditions, and orally ingested and topically applied oils containing ε-linoleic acid improve skin barrier functioning.
Topical treatment with sacran, a sulfated polysaccharide from Aphanothece sacrum, improves corneocyte‐derived parameters
The results indicate that the sulfated polysaccharide sacran is an effective agent for improving or maintaining the skin conditions.
Use of emollients in dry‐skin conditions: consensus statement
A group of clinical professionals covering acute community‐care settings and medicines management met to review current data and practice to support other professionals in their approach to the use of emollient therapies in dry‐skin conditions.
Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis
This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components.
Cleansing‐induced changes in skin measured by in vivo confocal raman spectroscopy
  • M. Davies
  • Medicine
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
  • 2019
One of the most important steps people can take in reducing the spread of bacteria and viruses is washing the hands with soap and water. Frequent washing, required in certain occupations, can lead to
Moisturizer in Patients with Inflammatory Skin Diseases
Basic cosmetics, especially moisturizers, should be recommended in consideration of the ingredients, effectiveness and safety of each product, and the skin condition of each patient, according to a patient’s skin condition.
Molecular basis for stratum corneum maturation and moisturization
  • A. Rawlings
  • Medicine
    The British journal of dermatology
  • 2014
An update on the latest developments for the molecular basis of SC maturation and moisturization, while highlighting the contributions of Professor Marks in the different areas is provided.
Understanding and treating various skin types: the Baumann Skin Type Indicator.
Moisturization and skin barrier function
The present paper reviews the current understanding of the biology of the stratum corneum, particularly its homeostatic mechanisms of hydration, and discusses how each maturation step leading to the formation of an effective moisture barrier—including corneocyte strengthening, lipid processing, and NMF generation—is influenced by the level of SC hydration.


Reduction of AHA irritation potential by inclusion of a saccharide isomerate
Twelve subjects with normal to dry and slightly sensitive skin applied test materials,(5% lactic acid creams, pH 3.0 with and without 5% pentavitan TM [saccharide isomerate]) to the left and right
Epidermal lipids, barrier function, and desquamation.
  • P. Elias
  • Computer Science
    The Journal of investigative dermatology
  • 1983
A heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum Corneum barrier function and desquamation is proposed.
Two randomized, double-blind comparison studies were conducted to evaluate the efforts of 2 emollient dry skin creams containing urea in the management of dry skin in atopic patients. Cream with 10%
Effect of a skin cream containing the sodium salt of pifrollidone oarboxiflio acid on dry and flaky skin
Humectants added to skin creams can increase the moisture retention of isolated stratum corneum and reduce the incidence of dry and flaky skin in vivo. This paper gives results of an investigation
Alpha hydroxyacids modulate stratum corneum barrier function
This study shows that AHAs can modulate stratum corneum barrier function and prevent skin irritation: the effect is not equal for all AHAs.
The effect of glycerol and humidity on desmosome degradation in stratum corneum
One of the major actions of moisturizers in vivo is to aid the digestion of desmosomes which are abnormally retained in the superficial layers of xerotic stratum corneum, according to this investigation.
Biophysical methods of providing objective documentation of the effects of moisturizing creams
  • M. Lóden
  • Medicine
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
  • 1995
This review provides some insight into how performance of moisturizers can be measured.
10% urea cream (Laceran) for atopic dermatitis: A clinical and laboratory evaluation
Clinical results and evaporimetric data showed that twice daily applications of urea cream improved the dryness, the itching and the erythema of patients with atopic dermatitis.
A new method to evaluate the softening effect of cosmetic ingredients on the skin
The extent of plasticization of the stratum corneum by aqueous humectant solutions varied depending on their water-holding capacities. It was determined that the higher the water-holding capacity,