Effects of NSAID use on bone healing: A meta-analysis of retrospective case–control and cohort studies within clinical settings

  title={Effects of NSAID use on bone healing: A meta-analysis of retrospective case–control and cohort studies within clinical settings},
  author={Muhammad Usman Ali and Mehvish Usman and Kuntal Patel},
  pages={111 - 94}
Introduction This meta-analysis aims to determine whether non-steroidal anti-inflammatory drug (NSAID) use is significantly associated with adverse bone healing outcomes within clinical settings, including trauma and elective spine settings. It will also explore bone healing outcomes with the type, route, dosage and duration of NSAID exposure and aims to demonstrate the effects of various other confounding factors on bone healing outcomes. Methods Electronic databases including MedLine, Embase… 
4 Citations

Figures and Tables from this paper

Pain Management Strategies After Orthopaedic Trauma: A Mixed-Methods Study with a View to Optimizing Practices
It is found that opioids are still the leading pain management strategy after an orthopaedic trauma and that more efforts are needed to implement non-pharmacological strategies.
Management of Pain Associated with Fractures
The literature is still inconclusive regarding superiority of either spinal or general anesthesia during operative treatment on common fracture types, requiring nuanced clinical judgment in the face of mixed clinical findings.


Nonsteroidal Anti‐Inflammatory Drugs and Bone‐Healing: A Systematic Review of Research Quality
There is no consensus regarding the safety of NSAIDs following orthopaedic procedures, and future studies should aim for appropriate methodological designs to help to clarify existing discrepancies to improve the quality of care for orthopedic patients.
The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies
NSAID appear to have dose-dependent and duration-dependent effects on fusion rates, and spine surgeons can consider the incorporation of NSAIDs into pain control regimens for spinal fusion patients with the goal of improving pain control and reducing the costs and complications associated with opioids.
Nonsteroidal anti-inflammatory drugs’ impact on nonunion and infection rates in long-bone fractures
LBF patients who received NSAIDs in the postoperative period were twice as likely and smokers more than three times likely to suffer complications such as nonunion/malunion or infection, and are advised to avoid NSAID in traumatic LBF.
Postoperative Aspirin Use is Associated with Delayed Progression of Radiographic Healing in Tibial Fractures Treated with Internal Fixation
The data suggest postoperative administration of ASA delays progression of radiographic fracture healing in tibial fractures treated with intramedullary fixation, and supports the notion that prostaglandin inhibition may have a negative effect on proper bony healing.
Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures
The first to prospectively examine time to union, as well as major complications of the fracture healing process, while adjusting for potential confounders, highlights the need for orthopaedic surgeons to encourage their patients to enter a smoking cessation programs.
Effect of Nonsteroidal Antiinflammatory Drugs on Fracture Healing: A Laboratory Study in Rats
It is suggested that NSAIDs have an inhibitory effect on fracture repair that is reversible after cessation of indomethacin but not ibuprofen, and this effect is noticeable earlier than the difference found by mechanical testing of bone.
Do nonsteroidal anti-inflammatory drugs affect the outcome of arthroscopic Bankart repair?
Prescription of short‐term post‐operative NSAID treatment in the post-operative period did not influence on the functional outcome after arthroscopic Bankart procedures.
Nonsteroidal antiinflammatory drugs for postoperative pain management after lumbar spine surgery: a meta-analysis of randomized controlled trials.
This meta-analysis provides evidence that the addition of NSAIDs to opioid analgesics in lumbar spine surgery provided better pain control than opioid analgesic alone.
Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database
Diabetes, NSAID use, and a recent motor vehicle accident were most consistently associated with an increased risk of a fracture-healing complication, regardless of fracture site or specific fracture- healing complication.