Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach.

@article{Breier1998EffectsON,
  title={Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach.},
  author={Almut Breier and Caleb M. Adler and Neil I. Weisenfeld and T P Su and Igor Elman and Lisa Picken and Anil K. Malhotra and David Pickar},
  journal={Synapse},
  year={1998},
  volume={29 2},
  pages={
          142-7
        }
}
Agents that antagonize the glutamatergic N-methyl-d-aspartate (NMDA) receptor, such as phenylcyclidine (PCP) and ketamine, produce a behavioral state in healthy volunteers that resembles some aspects of schizophrenia. A dysfunction in NMDA-dopaminergic interactions has been proposed as a mechanism for these behavioral effects. In this study, we examined the effects of ketamine on striatal dopamine release in healthy human subjects with a novel 11C-raclopride/PET displacement paradigm and… CONTINUE READING
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