Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models.

@article{Yamamoto1995EffectsON,
  title={Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models.},
  author={Atsushi Yamamoto and Takehisa Iwama and Hiroshi Takeda and Hiroichi Nagai},
  journal={Japanese journal of pharmacology},
  year={1995},
  volume={68 1},
  pages={
          47-55
        }
}
We examined the effect of a newly synthesized pyridazinone derivative, NIP-502 [4-chloro-5-(3-ethoxy)-4-phenoxybenzamine)-3(2H)-pyridazinone], on antigen-induced bronchial responses and allergic reactions in several animal models. NIP-502 (10 mg/kg, p.o.) inhibited the antigen-induced immediate asthmatic response in passively sensitized guinea pigs. The inhibitory effect was also observed in metyrapone (an inhibitor of 11 beta-hydroxylase)-pretreated guinea pigs. NIP-502 improved ovalbumin (OA… 
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