Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models.

  title={Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models.},
  author={Atsushi Yamamoto and Takehisa Iwama and Hiroshi Takeda and Hiroichi Nagai},
  journal={Japanese journal of pharmacology},
  volume={68 1},
We examined the effect of a newly synthesized pyridazinone derivative, NIP-502 [4-chloro-5-(3-ethoxy)-4-phenoxybenzamine)-3(2H)-pyridazinone], on antigen-induced bronchial responses and allergic reactions in several animal models. NIP-502 (10 mg/kg, p.o.) inhibited the antigen-induced immediate asthmatic response in passively sensitized guinea pigs. The inhibitory effect was also observed in metyrapone (an inhibitor of 11 beta-hydroxylase)-pretreated guinea pigs. NIP-502 improved ovalbumin (OA… 

The difference in citric acid-induced cough in congenitally bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs.

It was revealed that airway smooth muscle contraction and functional and/or morphological development of airway nervous receptors, especially C-fiber endings, contributed to aggravation of coughing in BHS.

Anti‐asthma effect of an antiviral drug, acyclovir: a clinical case and experimental study

  • H. OkadaT. Ohnishi T. Todani
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1997
An asthmatic patient's peak flow rate is improved by oral administration of acyclovir, which is an antiviral drug that inhibits DNA polymerase of herpes virus.

Diverse Biologically Active Pyridazine Analogs: A Scaffold for the Highly Functionalized Heterocyclic Compounds

  • M. Asif
  • Chemistry, Biology
    Review Journal of Chemistry
  • 2018
Pyridazine derivatives were reported to show antibacterial, antifungal, and antiviral properties, which makes them attractive synthetic compounds for designing and development of the novel pyridazines and phthalazines drugs in future.

Exploring Potential, Synthetic Methods and General Chemistry of Pyridazine and Pyridazinone: A Brief Introduction

This article is sincere attempt to review chemistry, synthesis, spectral studies and applications of pyridazinone.

Pharmacological activities of pyridazines and pyridazinone Derivatives: A Review on biologically active scaffold

Pyridazine and pyridazinone derivatives compounds are biologically important compounds that give all types of biological activities such as analgesic, antiinflammatory, antimicrobial, antisecretory, antiulcer, antidepressants, neuroleptics, anxiolytics, sedative, hypnotic, tranquillizer, anticonvulsant, antiplatelet, antithrombotics and various other types of activities.

Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity

The influence of structural changes on the pharmacodynamic profile of the pyridazinone moiety is reviewed and several drugs based on its nucleus come into light.

The effect of pyridazine compounds on the cardiovascular system

Pyridazinones further draw focused attention because of their easy fictionalization at various ring positions, which makes them attractive synthetic compounds for designing and development of novel pyridrazinone as cardiotonic agents in future.



Effects of NZ-107 on bronchoconstriction in guinea pigs.

NZ-107 showed a tendency to inhibit accelerated severe asthmatic respiration more strongly in metyrapone-treated animals than in those treated with saline, and inhibition of platelet-activating factor at a dose of 0.2 mg/kg inhibited PAF-induced airway hyperreactivity.

In vitro studies of antigen-induced bronchospasm: effect of antihistamine and SRS-A antagonist on response of sensitized guinea pig and human airways to antigen.

It is suggested that both histamine and SRS-A are involved in the response of sensitized guinea pig and human airway tissue to antigen, with histamine mediating the early phase of the contraction and S RS-A primarily mediates the protracted phase.

Pharmacological study of bacterial lipopolysaccharide-induced airway hyperresponsiveness in guinea-pigs.

Results indicate that increased permeability in pulmonary capillaries is an important factor in the induction of lipopolysaccharide-induced bronchial hyperreactivity in guinea-pigs, and that this model is useful for the pharmacological study of airwayhyperreactivity.

Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea‐pigs: the effect of anti‐asthma drugs

Although eosinophilia may occur in association with increased airway reactivity in this animal model, there is no evidence of a causal relationship.

Late asthmatic response to Ascaris antigen challenge in dogs treated with metyrapone.

It is concluded that cortisol depletion augments the occurrence of theLate asthmatic response and ragweed challenge with metyrapone caused no change in Rrs, and the present dog model may be a useful tool for study of the late response in bronchial asthma.

Effects of NZ‐107 on Airway Inflammation and Cell Activation in Guinea‐pigs

It is indicated that NZ‐107 prevents the increased number of pulmonary eosinophils and airway epithelial cells and the activation of macrophages and eos inophils, suggesting thatNZ‐107 may be useful as a remedy for airway inflammatory diseases such as bronchial asthma.

Inhibition of hypersensitivity reactions by soluble derivatives of baicalein.

The experimental asthma caused by passive systemic anaphylaxis in guinea pigs was prevented with application of BPS, and BPS appears to be clinically applicable to extensive allergy related diseases.

Regulation of homocytotropic antibody formation in the rat. I. Feed-back regulation by passively administered antibody.

Results suggest that the inhibitory cell interaction in the rat HTA formation, which has previously been reported by us, is mediated by this subcellular component of primed T cell which is not immunoglobulin in nature but has an affinity and specificity to the carrier molecule.