Effects of NADPH oxidase inhibitor in diabetic nephropathy.

  title={Effects of NADPH oxidase inhibitor in diabetic nephropathy.},
  author={Kensuke Asaba and Akihiro Tojo and Maristela Lika Onozato and Atsuo Goto and Mark T Quinn and Toshiro Fujita and Christopher Stuart Wilcox},
  journal={Kidney international},
  volume={67 5},
BACKGROUND We used apocynin to test the hypothesis that superoxide anion (O(-) (2)) from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase underlies the development of diabetic nephropathy in the rat. METHODS Rats received apocynin (16 mg/kg/day) from 2 to 8 weeks after inducing diabetes mellitus (DM) with streptozotocin. RESULTS DM increased excretion of hydrogen peroxide (H(2)O(2)), lipid peroxidation products (LPO), nitric oxide products (NOx), and protein. The kidneys of rats… CONTINUE READING


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