Effects of N-acetylcysteine on dense cell formation in sickle cell disease.

@article{Pace2003EffectsON,
  title={Effects of N-acetylcysteine on dense cell formation in sickle cell disease.},
  author={Betty S Pace and Archil Shartava and Ardie Pack-Mabien and M. Mulekar and Alfredo Ardia and Steven R. Goodman},
  journal={American journal of hematology},
  year={2003},
  volume={73 1},
  pages={
          26-32
        }
}
  • Betty S Pace, Archil Shartava, +3 authors Steven R. Goodman
  • Published 2003
  • Medicine
  • American journal of hematology
  • The extent to which dense and irreversible sickle cells (ISCs) contribute to vaso-occlusive episodes in sickle cell disease remains unclear. N-Acetylcysteine (NAC) inhibits dense cell and ISC formation in sickle erythrocytes in vitro and restores glutathione levels toward normal. A phase II double-blind randomized clinical trial was completed to determine the efficacy of NAC in decreasing dense cell and ISC formation, and vaso-occlusive episodes in sickle cell disease. Twenty-one subjects with… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The primary aim of this study is to evaluate the effect of the drug N-Acetylcysteine on the frequency of pain in daily life in patients with Sickle Cell Disease (SCD). Pain is an… Expand
    ConditionsSickle Cell Disease
    InterventionDrug

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 74 CITATIONS, ESTIMATED 45% COVERAGE

    Advances in the Treatment of Sickle Cell Disease

    VIEW 1 EXCERPT
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2004
    2020

    CITATION STATISTICS

    • 3 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 29 REFERENCES

    N-acetylcysteine replenishes glutathione in HIV infection.

    VIEW 1 EXCERPT