Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12.

@article{Penugonda2005EffectsON,
  title={Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12.},
  author={Suman Penugonda and Suneetha Mare and Glenn D. Goldstein and W. A. Banks and Nuran Ercal},
  journal={Brain research},
  year={2005},
  volume={1056 2},
  pages={132-8}
}
Oxidative stress plays an important role in neuronal cell death associated with many different neurodegenerative conditions such as cerebral ischemia and Parkinson's disease. Elevated levels of glutamate are thought to be responsible for CNS disorders through various mechanisms causing oxidative stress induced by a nonreceptor-mediated oxidative pathway which blocks cystine uptake and results in depletion of intracellular glutathione (GSH). The newly designed amide form of N-acetylcysteine (NAC… CONTINUE READING

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