Effects of Monobutyl and Di(n-butyl) Phthalate in Vitro on Steroidogenesis and Leydig Cell Aggregation in Fetal Testis Explants from the Rat: Comparison with Effects in Vivo in the Fetal Rat and Neonatal Marmoset and in Vitro in the Human

@inproceedings{Hallmark2007EffectsOM,
  title={Effects of Monobutyl and Di(n-butyl) Phthalate in Vitro on Steroidogenesis and Leydig Cell Aggregation in Fetal Testis Explants from the Rat: Comparison with Effects in Vivo in the Fetal Rat and Neonatal Marmoset and in Vitro in the Human},
  author={Nina Hallmark and Marion Walker and Chris McKinnell and Isobel Kim Mahood and Hayley Scott and Rosemary Bayne and Shiona M. Coutts and Richard A. Anderson and Irene Greig and Keith D. Morris and Richard M. Sharpe},
  booktitle={Environmental health perspectives},
  year={2007}
}
BACKGROUND Certain phthalates can impair Leydig cell distribution and steroidogenesis in the fetal rat in utero, but it is unknown whether similar effects might occur in the human. OBJECTIVES Our aim in this study was to investigate the effects of di(n-butyl) phthalate (DBP), or its metabolite monobutyl phthalate (MBP), on testosterone production and Leydig cell aggregation (LCA) in fetal testis explants from the rat and human, and to compare the results with in vivo findings for DBP-exposed… CONTINUE READING