Corpus ID: 74003580

Effects of Momordica charentia and Tinospora cordifolia extract on intestinal drug transporter pump: P-glycoprotein

@article{Harle2004EffectsOM,
  title={Effects of Momordica charentia and Tinospora cordifolia extract on intestinal drug transporter pump: P-glycoprotein},
  author={U. Harle and N. Gaikwad},
  journal={Indian Journal of Pharmacology},
  year={2004},
  volume={36},
  pages={319-320}
}
Sir, P-glycoprotein (Pgp) is a 170-kD plasma membrane glycoprotein, which functions as an ATP-dependent transporter pump occurring in many parts of the body including the apical brush border of the intestinal membrane, (where it functions as a drug transporter). Pgp is major site for pharmacokinetic interaction as the substrates and modulators of Pgp can affect various pharmacokinetic parameters. Pgp substrates include Anthracyclines e.g. Doxorubicin, Vinca alkaloids e.g. Vinblastine, Steroids… Expand
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