Effects of Molecular Crowding on the Dynamics of Intrinsically Disordered Proteins

@inproceedings{Cino2012EffectsOM,
  title={Effects of Molecular Crowding on the Dynamics of Intrinsically Disordered Proteins},
  author={Elio A. Cino and Mikko Karttunen and Wing-Yiu Choy},
  booktitle={PloS one},
  year={2012}
}
Inside cells, the concentration of macromolecules can reach up to 400 g/L. In such crowded environments, proteins are expected to behave differently than in vitro. It has been shown that the stability and the folding rate of a globular protein can be altered by the excluded volume effect produced by a high density of macromolecules. However, macromolecular crowding effects on intrinsically disordered proteins (IDPs) are less explored. These proteins can be extremely dynamic and potentially… CONTINUE READING

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