Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function.


Cardiac gene delivery of parvalbumin (Parv), an EF-hand Ca(2+) buffer, has been studied as a therapeutic strategy for diastolic heart failure, in which slow Ca(2+) reuptake is an important contributor. A limitation of wild-type (WT) Parv is the significant trade-off between faster relaxation and blunted contraction amplitude, occurring because WT-Parv… (More)
DOI: 10.1016/j.bpj.2016.03.037