Effects of Mg and Mn ions on the inhibitory action of cyclic nucleotides in the longitudinal myometrium of rat.

@article{Osa1994EffectsOM,
  title={Effects of Mg and Mn ions on the inhibitory action of cyclic nucleotides in the longitudinal myometrium of rat.},
  author={Toshihiro Osa and Hiroyoshi Inoue and Naoko Todoroki and Donghui Cui},
  journal={The Japanese journal of physiology},
  year={1994},
  volume={44 1},
  pages={
          49-66
        }
}
Contractile response, membrane activity, and fluorescence signal from mag-fura-2 were measured on the longitudinal myometrium taken from estrogen-treated rat, and the influence of Mg and Mn ions on the inhibitory effects caused by db cAMP, 8-bromo cGMP, and db cGMP was investigated. Taking the Kd value of mag-fura-2 with Mg to be 2.0 mM, the intracellular Mg concentration was estimated to be 380 microM in the tissue incubated with Mg-free Krebs solution and 420 microM in the tissue exposed to… CONTINUE READING
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