Effects of Methylphenidate and Bupropion on DHEA-S and Cortisol Plasma Levels in Attention-deficit Hyperactivity Disorder

  title={Effects of Methylphenidate and Bupropion on DHEA-S and Cortisol Plasma Levels in Attention-deficit Hyperactivity Disorder},
  author={Moon-Soo Lee and Jaewon Yang and Young-Hoon Ko and Changsu Han and Seung-hyun Kim and Min-Soo Lee and Sook Haeng Joe and In-Kwa Jung},
  journal={Child Psychiatry and Human Development},
We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels… 

Salivary dehydroepiandrosterone, but not cortisol, is associated with attention deficit hyperactivity disorder

  • Liang-Jen WangYu-Shu Huang Chih-Ken Chen
  • Medicine, Psychology
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2011
DHEA, but not the cortisol basal level, may be a biological laboratory marker for ADHD, particularly for performance on the CPT, and the role of DHEA in treating ADHD require further investigation.

Effect of one-month treatment with methylphenidate on salivary cortisol level of attention deficit hyperactivity disorder children

There was a statistically significant decrease in salivary cortisol level of the ADHD group, specifically hyperactive/impulsive subtype compared to the control group and a statisticallysignificant increase of salivARY cortisol level after treatment compared to before treatment in the ADHDgroup.

Effects of stimulants and atomoxetine on cortisol levels in children with ADHD

Salivary neurosteroid levels and behavioural profiles of children with attention-deficit/hyperactivity disorder during six months of methylphenidate treatment.

Evidence that MPH administration might affect DHEA levels and D HEA/cortisol ratios is provided, and whether levels of neurosteroids are directly associated with brain function or behavioral problems in ADHD patients warrants further investigation.

The Trend in Morning Levels of Salivary Cortisol in Children With ADHD During 6 Months of Methylphenidate Treatment

The cortisol levels of ADHD patients increased significantly after 1 month of MPH treatment before decreasing to an intermediate level, but were significantly positively correlated with neuropsychological performance throughout the 6-month treatment period.

Does Methylphenidate Reduce Testosterone Levels in Humans? A Prospective Study in Children with Attention-Deficit/Hyperactivity Disorder

It is suggested that short-term treatment with methylphenidate at usual doses does not significantly alter salivary testosterone levels in attention-deficit/hyperactivity disorder patients, and future studies should clarify whether long-term methylphenidates disrupts testosterone production as well as the function of the reproductive system.



Three-Month Treatment Course of Methylphenidate Increases Plasma Levels of Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-Sulfate (DHEA-S) in Attention Deficit Hyperactivity Disorder

DHEA and DHEA-S may play a role in the therapeutic effects of methylphenidate, and several mechanisms to explain this action are proposed, including involvement of the serotonergic, GABA-ergic and noradrenergic pathways.

Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder.

In this double-blind, crossover trial, bupropion and methylphenidate were both effective and did not differ in their overall efficacy as treatments for ADHD.

Bupropion hydrochloride in attention deficit disorder with hyperactivity.

Bupropion may be a useful addition to available treatments for ADDH and comparative trials with such standard drugs as methylphenidate are warranted to determine the relative clinical merits of bupropion.

Analysis of neurosteroid levels in attention deficit hyperactivity disorder.

Using median blood levels as a cut-off indicator, higher blood levels of DHEA and DHEAS were associated with fewer ADHD symptoms, in particular hyperactivity symptomatology, suggesting a possible protective effect of various neurosteroids on the expression of ADHD symptom atology.

The Neuropsychopharmacology of Attention-Deficit/Hyperactivity Disorder

  • S. Pliszka
  • Psychology, Biology
    Biological Psychiatry
  • 2005

Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.

The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants.

Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia.

The preliminary observations report for the first time in double-blind fashion the efficacy of DHEA augmentation in the management of negative, depressive, and anxiety symptoms of schizophrenia.

Methylphenidate: its pharmacology and uses.

The current understanding of the mechanism of action and efficacy of methylphenidate in various clinical conditions is reviewed.

The Influence of Hormones and Pharmaceutical Agents on DHEA and DHEA‐S Concentrations: A Review of Clinical Studies

As research moves forward to better understand the relationships of these adrenal androgens with health and disease, it is essential that studies be designed to control for the influence of administered pharmaceuticals on DHEA and D HEA‐S.

Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age.

The relation between levels in the blood and CSF differ for each of these three neuroactive steroids, showing the brain is exposed to relatively high levels of DHEA and DHEAS during later childhood and early adulthood but to relatively or absolutelyhigh levels of cortisol during infancy and older age.