• Corpus ID: 55553229

Effects of Methylglyoxal, TNF-α and IL-1α on Proteoglycan Synthesis in Human Endothelial Cells in vitro

@inproceedings{Johansen2007EffectsOM,
  title={Effects of Methylglyoxal, TNF-$\alpha$ and IL-1$\alpha$ on Proteoglycan Synthesis in Human Endothelial Cells in vitro},
  author={Lisa M. Johansen and Svein O Kolset and Katja Svennevig and Annicke Stranda},
  year={2007}
}

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TLDR
In both diabetic and uremic patients, these dicarbonyl compounds promote AGE accumulation in vivo, and especially in uremi patients, increased accumulation of GO could result from accelerating oxidative stress.
High glucose and Nε-(carboxymethyl) lysine bovine serum albumin modulate release of matrix metalloproteinases in cultured human endothelial cells
TLDR
The HUVEC exposed to high glucose or AGE exhibit decreased secretion of MMP-2, which may be relevant in understanding the altered turnover of the endothelial extracellular matrix observed in the diabetic state.
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The elicitation of leukocytes from the circulation to inflamed tissue depends on the activation of both the leukocyte and endothelial cell. In this study we determined the gene expression and
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