Effects of Metformin With or Without Supplementation With Folate on Homocysteine Levels and Vascular Endothelium of Women With Polycystic Ovary Syndrome

@inproceedings{Palomba2010EffectsOM,
  title={Effects of Metformin With or Without Supplementation With Folate on Homocysteine Levels and Vascular Endothelium of Women With Polycystic Ovary Syndrome},
  author={Stefano Palomba and Angela I Falbo and Francesco Giallauria and Tommaso Russo and Achille Tolino and Fulvio Zullo and Annamaria Colao and Francesco Orio},
  booktitle={Diabetes care},
  year={2010}
}
OBJECTIVE To evaluate whether the administration of metformin exerts any effects on serum homocysteine (Hcy) levels in patients with polycystic ovary syndrome (PCOS) and whether supplementation with folate enhances the positive effects of metformin on the structure and function of the vascular endothelium. RESEARCH DESIGN AND METHODS A total of 50 patients affected by PCOS, without additional metabolic or cardiovascular diseases, were enrolled in a prospective nonrandomized placebo-controlled… CONTINUE READING

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