Effects of Melatonin on Ischemia and Reperfusion Injury of the Rat Heart

  title={Effects of Melatonin on Ischemia and Reperfusion Injury of the Rat Heart},
  author={Ondřej Sz{\'a}rszoi and G Asemu and Jir{\'i} Vanecek and Bohuslav O{\vs}t'{\'a}dal and Franti{\vs}ek Kol{\'a}ř},
  journal={Cardiovascular Drugs and Therapy},
Effects of melatonin on various manifestations of ischemia/reperfusion injury of the isolated perfused rat heart were examined. Ischemia- and reperfusion-induced ventricular arrhythmias were studied under constant flow in hearts subjected to 10, 15 or 25 min of regional ischemia (induced by LAD coronary artery occlusion) and 10-min reperfusion. Melatonin was added to the perfusion medium 5 min before ischemia at concentrations of 10 μmol/l or 10 nmol/l and was present throughout the experiment… CONTINUE READING


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