Effects of Melatonin in Perimenopausal and Menopausal Women: Our Personal Experience

  title={Effects of Melatonin in Perimenopausal and Menopausal Women: Our Personal Experience},
  author={G Bellipanni and Fernando L. Marzo and Federico B M Blasi and Antonio Marzo},
  journal={Annals of the New York Academy of Sciences},
The purpose of this clinical trial on possible effects of nocturnal MEL administration in perimenopausal women was to find if MEL by itself modifies levels of hormones and produces changes of any kind, independently of age (42-62 years of age) and the stage of the menstrual cycle. [] Key Method Subjects took a daily dose of 3 mg synthetic melatonin or a placebo for 6 months. Levels of melatonin were determined from five daily saliva samples taken at fixed times.

The effect of long-term melatonin supplementation on psychosomatic disorders in postmenopausal women.

It is concluded that melatonin supplementation therapy exerts a positive effect on psychosomatic symptoms in postmenopausal women and can be recommended as the useful adjuvant therapeutic option in treatment of these disorders.

Role of Pineal Hormone Melatonin in a Woman’s Life: From Conception to Decline of Life

Focus is given to melatonin effect on the female reproductive system, its participation in the aging process, and formation of pathological menopause, and research data on the effectiveness of the melatonin drug when tackling climacteric syndrome is presented.

Melatonin in perimenopausal and postmenopausal women: associations with mood, sleep, climacteric symptoms, and quality of life

Longitudinal research is needed to better understand the possible contributory role of menopause in lower melatonin levels and to evaluate melatonin’s influence on mood, sleep, vasomotor symptoms, and quality of life.

The effect of melatonin on the sexual function among postmenopausal women: A randomized placebo-controlled trial

Melatonin significantly improves sexual function among postmenopausal women and was significantly greater than the control group at all other assessment points.

Melatonin and the health of menopausal women: A systematic review

In light of multiple health benefits and an excellent safety profile, melatonin administration should be considered in menopausal women.

The features of optimal nonhormonal therapy of vegetative disorders among women with postmenopause

The use of Vitae-Melatonin at a dose of 3 mg/day in addition to phytotherapy in postmenopausal women had a clear clinical effect, which was a significant reduction of vegetative disorders, both compared to the initial indicators and in comparison with monophytotherapy.

Myo-inositol and melatonin in the menopausal transition

  • R. D'AnnaA. Santamaria S. Benvenga
  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2017
The combination of myo-Ins plus melatonin seems to affect positively glucose metabolism, while myo -Ins only seems to improve thyroid function in women during menopausal transition.

Insomnia and menopause: a narrative review on mechanisms and treatments

Cognitive behavioral therapy represents the first-line treatment of insomnia in the general population, regardless of the presence of mood disorders and/or vasomotor symptoms (VMS), and prolonged-released melatonin should represent a first- line drug in women aged ≥ 55 years.

The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia

Melatonin supplementation is useful in treating H. pylori -associated dyspepsia, particularly in postmenopausal women with lower levels of this hormone, and examine the role of Helicobacter infection.

Alternative Options to Manage Menopausal Symptoms with a Focus on Melatonin and Osteoporosis

The focus of this mini-review is to highlight the novel use of melatonin on managing menopausal symptoms and menopausal bone loss and describe food sources that are rich in melatonin.



Effects of melatonin in perimenopausal and menopausal women : a randomized and placebo controlled study

MEL decline during aging may signal the derangement of pineal and pituitary-controlled ovarian cyclicity and the progressive quenching of G. Pierpaoli in women, as well as show a recovery of pituitsary and thyroid functions in MEL-treated women, towards a more juvenile pattern of regulation.

Melatonin and human reproduction.

While correlations between melatonin and the status of the reproductive system in humans have been noted, whether they are functionally related remains to be determined.

Melatonin: a rediscovered antitumor hormone? Its relation to surface receptors; sex steroid metabolism, immunologic response, and chronobiologic factors in tumor growth and therapy.

Recent observations suggest that melatonin deserves clinical trial to enhance or modify response in hormonally sensitive tumors and to determine if melatonin’s impact on chronobiologic control can improve the circadian rhythm.

Chronobiology of pituitary-thyroid functions.

Circadian and circannual variations were found and described by cosinor analysis in the children as well as in the elderly subjects and there was no difference between the children with and without goiter in the circadian MESOR of any thyroid parameter or of TSH.

Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin.

The relative absence of MEL receptors from the human PT suggests that neuroendocrine responses to MEL in humans may occur by fundamentally different mechanisms than those that underlie the photoperiodic regulation of reproduction in seasonally breeding species.


Both salivary melatonin concentrations and urinary 6‐hydroxymelatonin sulphate excretion rates are reliable indices of serummelatonin concentrations, providing two convenient, non‐invasive techniques for monitoring melatonin circadian rhythmicity.

Hypothalamic‐pituitary ageing: progressive increase in FSH and LH concentrations throughout the reproductive life in regularly menstruating women *

Assessment of changes in gonadotrophin concentrations and the onset of these changes during the reproductive life prior to the perimenopause found reduced fertility and endocrine changes become more pronounced during theperimenopausal period.

Age-dependent reduction in serum melatonin concentrations in healthy human subjects.

Serum melatonin concentrations were determined by RIA in 81 healthy humans, aged 1–92 yr and the results suggest that serum melatonin may be secreted under the agerelated neural control of pineal metabolism.

Melatonin Regulates the Synthesis and Secretion of Several Proteins by Pars Tuberalis Cells of the Ovine Pituitary

Results confirm that melatonin‐responsive cells are secretory cells and imply that the PT‐specific product is not a protein, and demonstrate that in the ovine PT melatonin regulates the synthesis and export of several secretory proteins.