Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

@article{Vetvicka2021EffectsOM,
  title={Effects of Medicinal Fungi-Derived $\beta$-Glucan on Tumor Progression},
  author={V{\'a}clav Vetvicka and T. V. Teplyakova and Alexandra B Shintyapina and Tatiana A Korolenko},
  journal={Journal of Fungi},
  year={2021},
  volume={7}
}
β-Glucans have been studied in animal species, from earthworms to humans. They form a heterogenous group of glucose polymers found in fungi, plants, bacteria, and seaweed. β-Glucans have slowly emerged as an important target for the recognition of pathogens. In the current review, we highlight the major roles of mushroom-derived β-glucans on cancer progression. 
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References

SHOWING 1-10 OF 155 REFERENCES
Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential.
TLDR
The glucan, resveratrol, vitamin C combination was the strongest activator of phagocytosis and antibody formation and the results demonstrated that the combination strongly suppressed the growth of breast and lung tumors.
Molecular Interactions of β-(1→3)-Glucans with Their Receptors
TLDR
This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules.
β-Glucans and their applications in cancer therapy: focus on human studies.
  • E. Aleem
  • Biology, Medicine
    Anti-cancer agents in medicinal chemistry
  • 2013
TLDR
This review focuses on human studies; clinical trials and epidemiological data assessing the efficacy and safety of mushroom-derived β- glucans in cancer treatment and prevention and the potential direct effects of β-glucans on cancer cells are described.
Further study of the structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes.
Glucans as biological response modifiers.
TLDR
Physiological functions of glucan suggest the possible use of glucans not only as non-specific immunomodulator, but also as its possible future use as a drug.
Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota
TLDR
Investigation of the genoprotective effects of edible mushrooms revealed that mushrooms’ FSs have the ability to protect Caco-2 cells against tert-butyl hydroperoxide (t-BOOH), a known genotoxic agent.
Glucans and Cancer: Comparison of Commercially Available β-glucans - Part IV.
TLDR
The results showed significant differences among tested glucans, showing that despite the fact that glucans in general have strong stimulating effects on most aspects of the immune system, it is necessary to choose the right glucan.
The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis
TLDR
Applications of mushroom beta-glucans in conjunction with radiation therapy were effective in controlling tumor growth, and rate of metastasis, life threatening, and can potentially serve as a protective factor for wounds and hair loss that resulted from the overgrowth of primary tumor in LLC bearing mice.
Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic
TLDR
It is suggested that β-glucan may play an essential role in future strategies to prevent and inhibit tumor growth and the emerging success of combinatorial approaches to cancer treatment involving β- glucan is suggested.
Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver
TLDR
The effective lentinan dosage and route of administration for suppression of CYP1As is discussed, which is shown to possess the anti‐tumor and immunomodulating activities through the cytokine production from immunocytes.
...
...