Effects of MK-801 on the micturition reflex in the rat--possible sites of action.

@article{Yoshiyama1993EffectsOM,
  title={Effects of MK-801 on the micturition reflex in the rat--possible sites of action.},
  author={Mitsuharu Yoshiyama and James R. Roppolo and William Chet de Groat},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 2},
  pages={844-50}
}
The i.v. administration of MK-801 (dizocilpine), a noncompetitive N-methyl-D-aspartate receptor antagonist, depresses reflex bladder contractions in the rat, suggesting that glutamatergic transmission may have an important role in the micturition reflex pathway. The site of action of MK-801 was analyzed in the present experiments by studying the effects of the drug in the following urethane-anesthetized preparations: 1) intact rats, 2) decerebrate rats, 3) chronic spinal rats with transection… CONTINUE READING
24 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…