Effects of MDL 72222, a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats.

@article{Mckinzie2000EffectsOM,
  title={Effects of MDL 72222, a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats.},
  author={David L Mckinzie and William J H Mcbride and James M Murphy and Lawrence Lumeng and T. K. Li},
  journal={Alcoholism, clinical and experimental research},
  year={2000},
  volume={24 10},
  pages={1500-4}
}
BACKGROUND Previous studies indicated that, under continuous access conditions, the 5-HT3 antagonist MDL 72222 (MDL) effectively reduced ethanol drinking of alcohol-preferring P rats. However, MDL was without effect when similar doses were tested under scheduled access conditions, unless the ethanol access period was randomly presented. This study examined the effects of MDL on operant responding for ethanol and water by adult male alcohol-preferring P rats. METHODS During the dark cycle… CONTINUE READING

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