Effects of MAOA genotype and childhood experiences of physical and emotional abuse on aggressive behavior in adulthood

  title={Effects of MAOA genotype and childhood experiences of physical and emotional abuse on aggressive behavior in adulthood},
  author={Wail Rehan and N. Kenneth Sandnabba and Ada Johansson and Lars Westberg and Pekka Santtila},
  journal={Nordic Psychology},
  pages={301 - 312}
A functional polymorphism in the monoamine oxidase A (MAOA) gene located on the X chromosome (Xp11.23-11.4) has earned the nickname “warrior gene” because of its association with antisocial behavior and delinquency. Previous findings on adults and adolescents have found some evidence that the MAOA gene moderates the impact of childhood abuse experiences on the risk of developing aggressive behavior. Thus far, however, attempts to replicate these findings have been mixed. The aims of the present… 

Does MAOA increase susceptibility to prenatal stress in young children?

Experiences of severe childhood maltreatment, depression, anxiety and alcohol abuse among adults in Finland

Although the majority of severely abused or neglected individuals did not show clinical levels of depression, anxiety or alcohol use, severe childhood maltreatment increased the risk for showing clinical level of psychopathology in adulthood.

Some considerations on care of the elderly, using evolutionary genetic models

  • T. Miyo
  • Medicine
    World Journal of Advanced Research and Reviews
  • 2020
This study suggests that high levels of care for old parents could evolve within the population if the cost of care of the elderly is not too heavy, but it also suggests that, if younger generations experience a high cost of elderly care, this behavior might be eliminated from the population, resulting in the loss of high Levels of Care for infants.



Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype

Early Trauma and Increased Risk for Physical Aggression during Adulthood: The Moderating Role of MAOA Genotype

The hypothesis that MAOA genotype moderates the association between early traumatic life events experienced during the first 15 years of life and the display of physical aggression during adulthood is supported and the use of dimensional measures focusing on behavioral aspects of aggression may increase the likelihood of detecting significant gene-by-environment interactions in studies of MAOA-related aggression.

Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females

The main effect of MAOA on risk for CD in females, its absence in males and directional difference of interaction is suggestive of genotype–sex interaction, but as the effect of G×E onrisk for CD was weak, its inclusion is not justified.

Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment

  • B. HaberstickJ. Lessem J. Hewitt
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
This work did not replicate a previous report that MAOA polymorphisms moderated the relationship between maltreatment and conduct problems, and there was, however, a non‐significant trend in the predicted direction.

MAOA, maltreatment, and gene–environment interaction predicting children's mental health: new evidence and a meta-analysis

These findings provide the strongest evidence to date suggesting that the MAOA gene influences vulnerability to environmental stress, and that this biological process can be initiated early in life.

An Association between a Functional Polymorphism in the Monoamine Oxidase A Gene Promoter, Impulsive Traits and Early Abuse Experiences

The results suggest that the lower expression of the MAOA-uVNTR polymorphism is related to a history of early Abuse and may sensitize males, but not females, to the effects of early abuse experiences on impulsive traits in adulthood.

Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients.

The results of the current study do not support the hypothesis that a polymorphism in the gene encoding MAO-A contributes to the genetic risk for conduct disorder.

Role of Monoamine Oxidase A Genotype and Psychosocial Factors in Male Adolescent Criminal Activity