Effects of Low-Dose and Very Low-Dose Ketamine among Patients with Major Depression: a Systematic Review and Meta-Analysis.

@article{Xu2016EffectsOL,
  title={Effects of Low-Dose and Very Low-Dose Ketamine among Patients with Major Depression: a Systematic Review and Meta-Analysis.},
  author={Ying Xu and Maree Lisa Hackett and Gregory Carter and Colleen K. Loo and Ver{\`o}nica G{\'a}lvez and Nick S Glozier and Paul W Glue and Kyle A. B. Lapidus and Alexander McGirr and Andrew Alexander Somogyi and Philip B. Mitchell and Anthony Rodgers},
  journal={The international journal of neuropsychopharmacology},
  year={2016},
  volume={19 4}
}
BACKGROUND Several recent trials indicate low-dose ketamine produces rapid antidepressant effects. However, uncertainty remains in several areas: dose response, consistency across patient groups, effects on suicidality, and possible biases arising from crossover trials. METHODS A systematic search was conducted for relevant randomized trials in Medline, Embase, and PsycINFO databases up to August 2014. The primary endpoints were change in depression scale scores at days 1, 3 and 7, remission… CONTINUE READING