Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo

@inproceedings{GouniBerthold2013EffectsOL,
  title={Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo},
  author={Ioanna Gouni-Berthold and Heiner K. Berthold and Joo Young Huh and Reena Berman and Nadine Spenrath and Wilhelm Krone and Christos S. Mantzoros},
  booktitle={PloS one},
  year={2013}
}
CONTEXT AND OBJECTIVE The myokine irisin has been proposed to regulate energy homeostasis. Little is known about its association with metabolic parameters and especially with parameters influencing pathways of lipid metabolism. In the context of a clinical trial, an exploratory post hoc analysis has been performed in healthy subjects to determine whether simvastatin and/or ezetimibe influence serum irisin levels. The direct effects of simvastatin on irisin were also examined in primary human… CONTINUE READING

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