Effects of Lidocaine on Cytosolic pH Regulation and Stimulus-Induced Effector Functions in Alveolar Macrophages

Abstract

Local anesthetics influence a variety of stimulus-induced effector functions in leukocytes. The present study determined the effects of lidocaine on intracellular pH (pHi) regulation, superoxide production, and tumor necrosis factor-α (TNF-α) release in alveolar macrophages (mφ). Resident mφ were obtained by bronchoalveolar lavage of rabbits. The cells were… (More)
DOI: 10.1007/PL00007581

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