Effects of Lavandula angustifolia essential oil on Interleukin 23 and Brain-Derived neurotrophic factor gene expression in peripheral blood mononuclear cells of multiple sclerosis patients

  title={Effects of Lavandula angustifolia essential oil on Interleukin 23 and Brain-Derived neurotrophic factor gene expression in peripheral blood mononuclear cells of multiple sclerosis patients},
  author={Soheil Rahmani Fard and Mohammad Ansari and Masoud Mehrpour and Mahbouba Ahmadi and S. Emamgholipour},
  journal={Medical laboratory sciences},
Introduction: We aimed to determine the effect of lavandula angustifolia essential oil (LEO) on IL-23 and brain-derived neurotrophic factor (BDNF) gene expressions in peripheral blood mononuclear cells (PBMCs) of relapse-remitting MS (RRMS) patients. Methods : LEO was prepared using the hydrodistilation method on the plants aerial parts.    8 female RRMS patients and 8 healthy sex and age matched controls were entered into this study. PBMC cells were separated using Ficoll method and were… 
1 Citations

Figures and Tables from this paper

Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender

Hundreds of millions of people around the world suffer from neurological disorders or have experienced them intermittently, which has significantly reduced their quality of life. The common



Effect of lavender essential oil on LPS-stimulated inflammation.

Treatment of 0.1% LEO significantly increased cell viability and inhibited the IL-1β and superoxide anion generation in LPS-stimulated THP-1 cells, suggesting that the LEO inhibited L PS-induced inflammatory effect might be associated with the expression of HSP70.

Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.

The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice

LO and its active component LI have protected the oxidative stress, activity of cholinergic function and expression of proteins of Nrf2/HO-1 pathway, and synaptic plasticity in AD.

Brain-derived neurotrophic factor in patients with multiple sclerosis

Increased Serum Brain-derived Neurotrophic Factor in Multiple Sclerosis Patients on Interferon-&bgr; and Its Impact on Functional Abilities

This study showed a significant effect of interferon-&bgr; 1b therapy on increasing BDNF production in multiple sclerosis.

Biological activities of Lavender essential oil

There does seem to be both scientific and clinical data that support the traditional uses of lavender, but methodological and oil identification problems have severely hampered the evaluation of the therapeutic significance of much of the research on Lavandula spp.

Cytokine Gene Expression in Newly Diagnosed Multiple Sclerosis Patients

Dysregulation of cytokines, mainly increased expression of pro-inflammatory cytokines and decreased expression of inhibitory cytokines occurred in MS patients, and this study may shed light to the probable role of these cytokines in neurodegeneration mechanism and current or future use of cytokine in managing and treatment of multiple sclerosis.

Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.

Findings on the expression of IL-23p19 in multiple sclerosis lesions may lead to a better understanding of the events culminating in human multiple sclerosis.

Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice

Treatment with lavender oil significantly decreased neurological deficit scores, infarct size, the levels of MDA, carbonyl and ROS, and attenuated neuronal damage, upregulated SOD, CAT, GSH-Px activities and GSH/GSSG ratio are suggested to be attributed to its antioxidant effects.

Increased levels of IL-23 and osteopontin in serum and cerebrospinal fluid of multiple sclerosis patients